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Moreover, the selectivity of such synthesized compounds was located to get appreciably bigger for HDAC6 compared to HDAC1 and HDAC8. Compound 96c turned out to be the simplest with the very best HDAC6 exercise but reasonable FGER1 activity.-alkylated indazole chloroacetamidine derivatives as potential protein arginine deiminase 4 (PAD4) inhibitors.